Global Cancer Nurse's Experiences and Perceptions of Potential Occupational Exposure to Cytotoxic Drugs: Mixed Method Systematic Review With Framework Synthesis.
Karen Campbell, Janyne Afseth, Margaret Dunham and 2 others
PMID 39468852WHAT IT FOUND
Across 38 global studies, nurses' safe handling of chemotherapy was shaped by workplace culture and barriers, not just knowledge.
Many reported skipping protective equipment due to discomfort, workload, or feeling their expertise made exposure impossible.
Key findings
01Six studies reported that a lack of wearing PPE was due to discomfort, work pressures, or availability.
02Seven studies reported a lack of knowledge of occupational exposure amongst their participants, while others reported adequate or high levels.
03Thirty-two studies utilised self-reported, subjective methodology, meaning responses reflect what nurses believe should occur rather than observed practice.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The review is dominated by self-reported data (32 of 38 studies), which may not reflect actual clinical practice. Only English-language studies were included, potentially missing relevant research from non-English speaking countries. The included studies were heterogeneous in design, population, and setting, making it difficult to draw universal conclusions. The framework used was adapted from a single prior model and has not been tested in practice.
Declared interests
The publication types indicate 'Research Support, Non-U.S. Gov't'. No specific financial conflicts of interest for the authors are detailed in the provided text.
The easy way to misread this
Do not assume that high knowledge of cytotoxic hazards translates to safe practice. The review found that many nurses skip PPE due to workload or discomfort, and self-reported safety perceptions often do not match observed adherence.