Falls, Cognitive Impairment, and Gait Performance: Results From the GOOD Initiative.
Gilles Allali, Cyrille P Launay, Helena M Blumen and 7 others
PMID 27914848WHAT IT FOUND
In older adults able to walk without help, non-Alzheimer dementia was linked to more falls than cognitively healthy adults, while Alzheimer dementia was not.
Slower walking speed tracked falls broadly; variable stride time did so mainly in cognitively healthy adults.
Key findings
01Among 2496 participants, fall prevalence was 25% in cognitively healthy individuals, 31% in people with mild cognitive impairment, and 55% in people with dementia, including 50% in Alzheimer disease and 64% in non-Alzheimer dementia.
02After adjustment, non-Alzheimer dementia was associated with more falls than cognitively healthy status (OR 2.31; 95% CI 1.56-3.42; P < .001), while Alzheimer dementia was not (OR 1.15; 95% CI 0.80-1.65; P = .446).
03Higher stride time variability was associated with falling in cognitively healthy individuals, amnestic mild cognitive impairment, non-amnestic mild cognitive impairment, and mild non-Alzheimer dementia, but not in the other groups; slower gait speed was associated with falling after adjustment in every group except mild Alzheimer dementia.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for RNs
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What it does not show
This was a cross-sectional analysis, so it can show association between cognitive status, gait, and falls, but it cannot show that any factor caused falls or that treatment would reduce falls. Falls were collected retrospectively by self-report, and the paper states that this is not the best approach for fall assessment; recall bias could affect reporting, especially in participants with cognitive impairment. Fall recording periods differed across centers: most centers used the previous 12 months, while Luxembourg used the previous 6 months. Alzheimer and non-Alzheimer dementia were classified by DSM-IV criteria and clinical assessment, not autopsy confirmation. The analysis included major covariates but could not include all risk factors because the cohorts were heterogeneous. Participants had to be able to walk without personal assistance, so findings may not apply to older adults who already need assistance to walk. Of 2717 initially recruited participants, 221 were excluded for missing gait, clinical, or cognitive data, leaving 2496 for analysis.
Declared interests
The authors declared no conflicts of interest.
The easy way to misread this
Do not conclude that slower walking speed or variable stride time caused falls. This was a cross-sectional study with retrospective self-reported falls, so it shows association only. Do not assume all dementia subtypes carry the same fall risk; after adjustment, non-Alzheimer dementia was associated with higher fall odds, while Alzheimer dementia and mild cognitive impairment were not associated with higher fall odds than cognitively healthy adults.