Factors Associated With Initiation of Mechanical Ventilation in Patients With Sepsis: Retrospective Observational Study.
Robert E Freundlich, Gen Li, Aleda Leis and 1 others
PMID 37652887WHAT IT FOUND
Sepsis patients can need mechanical ventilation in the first day or much later, and the factors linked to early and late ventilation differ.
Key findings
013891 patients (13.5%) required mechanical ventilation within 30 days after sepsis onset.
022046 of those patients (52.6%) required ventilation within 24 hours after sepsis onset.
03Risk factors for ventilation differed by timing: early ventilation was linked to male sex, lower SOFA score, higher SIRS score, septic shock, cardiac arrhythmias, chronic pulmonary disease, congestive heart failure, and laboratory values; later ventilation had similar comorbidities but not male sex, SOFA score, SIRS score, or septic shock.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
The study was done at one medical center with many surgical and tertiary referral patients, so it may not apply to hospitals with more medical or community admissions. Reasons for intubation and some processes of care were not analyzed. Noninvasive ventilation and high-flow nasal cannula use may have affected the models. Analyses used values at sepsis onset; earlier, later, or repeated values might have changed results. The time-varying model used only linear time, and more complex time functions were not tested. Because this was observational, it identifies associations but cannot show that any risk factor caused ventilation or that changing care would prevent it.
Declared interests
The paper is marked as supported by NIH extramural research funding; the supplied text does not report other conflicts of interest or a sponsor role.
The easy way to misread this
Do not conclude that treating these risk factors will reduce mechanical ventilation. The study only observed associations and did not test any intervention.