Exercise and physical activity for people with Progressive Supranuclear Palsy: a systematic review.

The review included only 11 studies, and their sample sizes ranged from 1 to 24 people, so the evidence base is too small to give reliable effect estimates. The studies used different interventions, outcome measures and designs, so their numerical results could not be combined. Method quality varied, with risk of bias rated low, medium or high, and many designs did not control for chance. Only immediate post-intervention outcomes were always measured; there were no data on medium or long-term effects. Adverse events, medications, comorbidities, quality of life, disability and burden of disease were usually not reported. Many interventions used complex research clinic equipment rather than equipment available to most people. The review did not include literature published in languages other than English, and initial title screening was done by one reviewer.

Do not read the small to moderate balance and gait changes as proof that exercise works for Progressive Supranuclear Palsy. The review included only 11 studies, their samples ranged from 1 to 24 participants, the numerical results could not be combined, and the effects were not statistically significant.