Evaluation of an Interactive, Educational Website Developed for Adolescents to Learn About Pediatric Clinical Trials: DigiKnowIt News.

The study measured self-reported attitudes and intentions, not actual enrollment in a real clinical trial. No outcome was named as the primary endpoint, and several findings were only marginal, so the positive attitude and familiarity results should not be treated as a single confirmed effect. Adolescents already had high self-efficacy and high knowledge at the start, leaving little room for the website to improve these scores. The website usage was tracked separately for parents and teens, but they may have used the same link, so dosage estimates may be inaccurate. Some intervention participants did not engage with the website despite reminders, so the effect on those who used it may be different from the effect on all families assigned to it. The willingness measure used a fake disease and did not let families discuss the decision together, which may not match real trial decisions.

Do not conclude that DigiKnowIt News makes families more likely to join a real clinical trial. The study did not show improved knowledge or willingness to participate, and the clearest changes were in familiarity, attitudes, and confidence.