PTOtherFrontiers in rehabilitation sciences2026

Evaluation of AI-generated exercise prescriptions for diverse cardiac conditions in rehabilitation: a simulation study using the DeepSeek model.

Luca Perrero, Menada Gardalini, Tatiana Bolgeo and 3 others

PMID 42682750

WHAT IT FOUND

An AI model wrote exercise plans for five made-up cardiac patients that two experts rated as safe and guideline-consistent.

No real patients were involved and no comparison to clinician-written plans was made. This is a proof-of-concept, not evidence the AI can prescribe exercise.

Key findings

01The AI generated a structured 30-day exercise program for every one of the five hypothetical cardiac scenarios, and two experienced cardiac rehabilitation specialists found no manifestly unsafe recommendations in any of them.

02Expert mean ratings on a 5-point scale were 4.5 for guideline adherence, 5.0 for safety, and 4.3 for clinical plausibility. Safety was the highest-rated domain (range 4.8–5.0, with four of five scenarios scoring the maximum), while clinical plausibility showed the most variability (range 4.1–4.4).

03The study involved no real patients, used only five hypothetical profiles, relied on subjective Likert-scale ratings by two reviewers, and did not compare the AI-generated plans to prescriptions written by experienced cardiac rehabilitation clinicians.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

No real patients were involved; all five profiles were hypothetical and constructed by the study team, so the findings say nothing about how the AI performs with actual clinical data, comorbidities, or patient-specific context. Only five scenarios were tested, covering common but not the full range of cardiac rehabilitation referrals; the authors themselves note the profiles do not encompass the full spectrum of clinical complexity seen in routine practice. There was no comparison group: the AI-generated plans were never compared side-by-side with prescriptions written by experienced cardiac rehabilitation clinicians, so it is unknown whether the AI matches, exceeds, or falls short of standard clinical practice. The evaluation relied on two reviewers' subjective Likert-scale ratings; no objective or standardised assessment framework was used, and no patient outcomes (adherence, functional capacity, adverse events) were measured. Only a single AI model (DeepSeek-V3) was tested, so the findings cannot be generalised to other large language models. The AI worked from static, one-time prompts and could not incorporate real-time physiological data, longitudinal training response, or dynamic clinical changes, which are central to ongoing exercise prescription. The authors acknowledge that large language models remain susceptible to hallucinations — generating inaccurate or fabricated information presented with confidence — which in a cardiac context could lead to inappropriate exercise recommendations if accepted without clinical review.

Declared interests

The authors declared that no financial support was received for the work or its publication. No industry sponsorship, study design involvement, or manuscript-writing contribution by a commercial entity was reported.

The easy way to misread this

Do not read the 4.5-to-5.0 expert ratings as evidence that an AI can safely prescribe cardiac rehabilitation exercise in place of a clinician. The study used five hypothetical patient descriptions, no real patients, no comparison to clinician-written plans, and subjective Likert-scale scoring by two reviewers. The authors themselves state that no conclusions can be drawn about clinical effectiveness, patient adherence, or long-term outcomes, and that clinician oversight remains essential for any potential use of these tools in practice.

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The study

Participants
No actual patients. Five hypothetical clinical profiles (recent MI, prior MI, atrial fibrillation, HFrEF, HFpEF) were created by the study team and fed to the AI model.
Certainty of evidence
Low

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Luca Perrero, Menada Gardalini, Tatiana Bolgeo, et al. Evaluation of AI-generated exercise prescriptions for diverse cardiac conditions in rehabilitation: a simulation study using the DeepSeek model. Frontiers in rehabilitation sciences. 2026.

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