Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.
Mitchell R Knisely, Qing Yang, Nic Stauffer and 6 others
PMID 36096903WHAT IT FOUND
In 86 people with sickle cell disease, one ICAM1 variant was linked to lower average pain ratings on a 0 to 10 scale.
The finding is exploratory and needs validation, so it should not change pain care.
Key findings
01Average pain was 4.0 among 86 participants.
02For ICAM1 rs1799969, participants without a minor allele reported average pain of 4.13, while those with a minor allele reported 1.25 (p=0.01).
03The ICAM1 association had an effect size of 1.30, while effect sizes for the other SNPs were small to medium.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study included only 86 participants, and some genotype groups were small. Only 11 candidate variants were tested, and no multiple-testing correction was applied. Pain was measured with one average-pain item, and acute and chronic pain were not distinguished. The findings are preliminary and need replication in larger, more geographically diverse samples.
Declared interests
The supplied text lists NIH extramural and non-U.S. government research support. It does not provide an author conflict-of-interest declaration.
The easy way to misread this
Do not use ICAM1 genotype to predict or manage pain. The study was exploratory, had 86 participants, tested 11 variants, and only one reached significance without multiple-testing correction.