Distinct Profiles of Morning and Evening Fatigue Co-Occurrence in Patients During Chemotherapy.
Fay Wright, Bruce A Cooper, Steven M Paul and 5 others
PMID 37084242WHAT IT FOUND
Patients who reported high fatigue both upon waking and before bed had significantly lower quality of life scores than those with low fatigue.
This group also experienced more anxiety, depression, pain, and sleep disturbance, and had lower physical function.
Key findings
01Patients in the highest fatigue classes had significantly lower physical and mental quality of life scores compared to those in the lowest fatigue classes.
02High co-occurring morning and evening fatigue was associated with higher levels of anxiety, depression, pain, and sleep disturbance, along with lower attentional function.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Characteristics associated with each fatigue profile were evaluated only at enrollment, so it is unclear how these associations change over time. The sample lacked diversity, limiting the ability to fully evaluate the impact of social determinants of health on fatigue profiles. The study design cannot determine whether fatigue drives other symptoms like anxiety and pain, or if they occur simultaneously or follow fatigue.
Declared interests
The authors have no conflicts of interest to disclose.
The easy way to misread this
Do not assume that treating fatigue alone will resolve the associated anxiety, depression, or pain. This study shows these symptoms co-occur in high-risk profiles but does not prove that fatigue causes them or that reducing fatigue will improve the other symptoms.