Digital health interventions for oncofertility in female patients: a systematic review.

Only five studies met inclusion criteria, so the evidence base is very small. All included interventions were web-based, so findings may not apply to mobile apps, wearable devices, virtual reality or face-to-face counseling. The studies differed in design, control groups, outcomes and timing, so the reviewers could not combine them statistically. The included interventions varied in design, so the review did not isolate which component produced each effect. Two preliminary studies had serious risk of bias in at least one domain, and two randomized trials had some concerns. Effectiveness was assessed immediately after the intervention in all five studies, and the authors called for long-term follow-up in future research. Some studies had no control group, and the included symptom outcomes focused on general reproductive health rather than genital pain or sexual dysfunction.

The authors declared no conflict of interest, and the study reported no funding.

Do not conclude that digital health interventions reliably improve oncofertility outcomes. Many outcomes did not differ from control, and the review included only five heterogeneous studies with several risk-of-bias concerns.