Developmental and epileptic encephalopathy with spike-wave activation in sleep: From the 'functional ablation' model to a neurodevelopmental network perspective.

WHAT IT FOUND

This theoretical review argues that D/EE-SWAS cognitive impairments are better understood through brain network dysfunction than by localizing lesions.

It proposes future research directions for connectomics and standardized assessment but offers no new clinical evidence or treatment guidelines.

What this paper is

This is a theoretical review proposing a shift from lesion-based to network-based models for understanding developmental and epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS). It discusses conceptual frameworks, future research directions, and methodological needs for neuroimaging and neuropsychology. It reports no original patient data, no clinical trial results, and no direct evidence on therapeutic interventions. There are no findings here to change clinical practice.

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