Decisional Regret in Long-Term Australian Allogeneic Hematopoietic Stem Cell Transplantation Survivors: A Cross-Sectional Survey.
Gemma McErlean, Caley Tapp, Lisa Brice and 13 others
PMID 37329124WHAT IT FOUND
In long-term Australian transplant survivors, 9.2% of 423 analysed people reported some decisional regret in the past 7 days.
Regret was linked with chronic GVHD burden, distress, depression, low quality of life, low income, sexual activity not resumed, and frequent medical care.
Key findings
01Of 423 analysed survivors, 9.2% reported some decisional regret in the past 7 days.
02Decisional regret was significantly associated with chronic GVHD, more severe GVHD and more affected organ systems, higher DASS 21 distress, depression diagnosis, lower FACT-BMT QoL, lower post-transplant income, failure to resume sexual activity, and medical care more than once a month.
03Regret was not significantly associated with anxiety, posttraumatic growth, pre-transplant cancer diagnosis, number of comorbidities, or secondary cancers.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study included only survivors alive years after transplant, so people who died from relapse, complications, or multi-morbidity were absent and may have had different regret levels. It was cross-sectional, so it cannot show whether regret caused the linked factors or the linked factors caused regret. Regret was measured by one unscored question at one time, which may miss fluctuating or deeper regret. Not all eligible survivors returned the survey, and 4% did not answer the regret question, so participation bias is possible. Respondents were mostly white/Caucasian (86.9%), limiting generalisation to other ethnic groups.
Declared interests
The authors declared no potential conflicts of interest. The article is listed as receiving NIH extramural and non-U.S. government research support.
The easy way to misread this
Do not conclude that chronic GVHD, depression, low income, or failure to resume sexual activity caused decisional regret. The survey measured regret and these factors at one time, so it can only show they occurred together.