Comprehensive Behavioral Phenotyping of a 16p11.2 Del Mouse Model for Neurodevelopmental Disorders.
Joseph F Lynch, Sarah L Ferri, Christopher Angelakos and 5 others
PMID 32857907WHAT IT FOUND
A mouse model of a common autism-associated genetic deletion shows lower body weight and grip strength.
Males had transient reflex deficits and better high-speed motor coordination. Females showed late-onset memory impairment. These are animal phenotypes, not human treatment outcomes.
Key findings
01Del m males had significantly lower body weight compared to WTs with weight differences at PND 8 and PND10.
02Del m males had significantly lower grip strength at all ages tested and Del m females had lower grip strength at PND21 and PND42, but not PND70.
03At PND70, Del m females did not spend more time sniffing the novel object at test compared to the last training session 24 hours prior, suggesting impaired memory for the object.
STILL TO COME
How it was doneWhat they found
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What it does not show
This is an animal study; findings in mice do not directly translate to human clinical practice. No direct comparisons were made between male and female mice within the same analysis. Sample sizes varied by experiment and were often based on litters rather than individual animals for developmental milestones.
Declared interests
The authors declare no conflicts of interest. The study was supported by non-US government funding.
The easy way to misread this
Do not apply these mouse phenotypes to human patients. This study describes biological markers in an animal model of a genetic syndrome, not the efficacy of any therapy for communication or motor disorders in humans.