Comparison of the performance of different nutritional indicators for predicting poststroke depression in older adults with ischemic stroke.

The study was done at a tertiary hospital in Shenzhen, so results may not apply to other settings. Only 239 patients were analysed, and the authors describe the sample as small. Depression was assessed only on the seventh hospital day, so later PSD after discharge was not measured. Nutritional indicators were measured only at admission, so the direction of association between malnutrition and PSD is uncertain. Most patients had mild neurological impairment; only 7.5% had NIHSS scores greater than five. The individual nutritional indicators did not predict PSD well, and the combined prediction was not externally validated.

Funded by the School of Nursing, Anhui Medical University; the funder had no role in design, data collection, analysis, writing or submission. The authors declared no conflicts of interest.

Do not conclude that albumin, GNRI or MNA-SF alone can screen patients reliably; the paper reported that these individual indicators were not able to predict PSD. The combined result also comes from a single hospital cohort with short follow-up and no external validation.