Combined Exercise and Game-Based Cognitive Training Intervention: Correlative Pilot Study of Neurotrophic and Inflammatory Biomarkers for Women With Breast Cancer.
Jamie Myers, Harsh B Pathak, Jianghua He and 4 others
PMID 36542098WHAT IT FOUND
No inflammatory biomarker changes were found, but combined exercise and cognitive games increased IGF-1 levels in women with breast cancer.
The IGF-1 increase did not correlate with self-reported cognitive function or intervention dose.
Key findings
01IGF-1 levels increased significantly in the intervention group between baseline and 4 weeks and between baseline and 16 weeks (p < .01).
02No between-group differences were found for inflammatory biomarkers across the three assessment timepoints.
03The IGF-1 increase correlated with Trail Making Test B improvement (r = 0.31, p = .02), but the statistical model did not show a significant association, and it did not correlate with self-reported cognitive function or intervention dose.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
30 participants were consented to the substudy, and no power calculation was done, so the study is exploratory. The study did not control for multiple testing across many biomarkers. The intervention group had more self-reported cognitive impairment, greater fatigue, and higher activity levels at baseline than the control group. Blood samples were not collected at a fixed time after the most recent exercise and cognitive game session. Daily activity levels were not measured objectively. Some control participants withdrew, declined blood collection, or had missed samples. The parent study intervention was described only briefly because detailed description was reserved for a future publication.
Declared interests
Support was provided by the University of Kansas School of Nursing 2021 Jean Johnson Award, Hiroshima University, the Japan Society for the Promotion of Science Kakenhi grant, a University of Kansas Cancer Center consortium grant from Children's Mercy Hospital, the University of Kansas Cancer Center, and the Kansas Institute for Precision Medicine COBRE. The paper does not state author conflicts of interest.
The easy way to misread this
Do not conclude that the combined exercise and game-based cognitive training improves cognition or that the IGF-1 rise proves a benefit. This was a small pilot with no power calculation and no control for multiple testing. The IGF-1 increase was not significantly correlated with self-reported cognitive function or intervention dose, and no inflammatory biomarker changes were found.