Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models.
Emily A Brown, Jonathan D Lautz, Tessa R Davis, Edward P Gniffke, Alison A W VanSchoiack, Steven C Neier, Noah Tashbook, Chiara Nicolini, Margaret Fahnestock, Adam G Schrum, Stephen E P Smith
PMID 30237867WHAT IT FOUND
This paper measures protein networks in the brains of mice engineered to mimic autism.
It finds no clinical effects, tests no therapies, and includes no human participants. There are no findings here to change how you treat patients.
What this paper is
This is a basic science study measuring protein interactions in the brain tissue of seven different mouse models of autism. It reports no clinical outcomes, no patient data, and no intervention effects. There is nothing here for a physical, occupational, or speech-language therapist to apply to patient care.
The easy way to misread this
Do not interpret the molecular differences between mouse models as evidence for distinct subtypes of autism in humans or as a basis for changing clinical practice. These are biological measurements in animals, not clinical outcomes in patients.