Central Blood Pressure and Augmentation Index in Older Adults With Intellectual Disabilities.
T I M Hilgenkamp, A Oppewal, M N Bohmer and 7 others
PMID 40653916WHAT IT FOUND
Older adults with intellectual disabilities show cardiovascular risk patterns similar to the general population, with women having higher central blood pressure than men.
However, these specific vascular measures did not correlate with a history of cardiovascular disease in this group.
Key findings
01Central blood pressure and augmentation index values in older adults with intellectual disabilities were similar to those in general population cohorts with known cardiovascular risk factors.
02Women in the older cohort (60+ years) had significantly higher central systolic blood pressure, augmentation pressure, and augmentation index than men.
03None of the measured haemodynamic variables (central blood pressure or augmentation index) showed a significant correlation with a history of cardiovascular disease.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTs
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What it does not show
The cross-sectional design prevents any conclusions about whether central blood pressure measures can predict future cardiovascular events. Data from the two cohorts could not be combined due to institutional and national data sharing restrictions, limiting statistical power for multivariate analyses. Missing data was common, particularly for physical activity and fitness measures, which may affect the generalisability of findings. Sample sizes for the oldest age groups (80-89 years) were very small, potentially skewing the results for those specific demographics.
Declared interests
The authors declare no conflicts of interest. The study was funded by the Health Research Board, the Department of Health in Ireland, the Department of General Practice at Erasmus MC, and the Academic Collaborative Research Center Healthy Ageing and Intellectual Disabilities.
The easy way to misread this
Do not interpret the lack of correlation between central blood pressure and cardiovascular disease history as evidence that central blood pressure is irrelevant in this population. The cross-sectional nature of the study means it cannot assess predictive value, and the small sample size for regression analyses may have obscured significant associations.
Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →