Cannabis Use and the Risk of Incident Venous Thromboembolism Among People With HIV: A Longitudinal Cohort Study in the United States.
Lara Haidar, Robin M Nance, Stephanie A Ruderman and 22 others
PMID 42017672WHAT IT FOUND
In 13,646 people with HIV, cannabis use was not linked to higher venous thromboembolism risk.
Daily, weekly, and infrequent use showed no higher risk.
Key findings
01The cohort included 13,646 people with HIV, and 315 (2.3%) experienced an incident venous thromboembolism event.
02In adjusted Model 1, no significant association was observed between cannabis use and incident venous thromboembolism: former use aHR 0.78 (95% CI 0.57–1.07) and current use aHR 0.74 (95% CI 0.51–1.06) compared with never use.
03In Model 2, cannabis-use frequency showed no association with incident venous thromboembolism: daily use aHR 0.62 (95% CI 0.38–1.04), weekly use aHR 0.81 (95% CI 0.47–1.40), infrequent current use aHR 0.78 (95% CI 0.51–1.18), and former use aHR 0.78 (95% CI 0.57–1.06) compared with never use.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
It was an observational cohort, so unmeasured factors may have affected the result. Cannabis use was self-reported, and social desirability could have caused underreporting. The study did not capture whether cannabis was recreational or medicinal, its concentration, dosage, or route of administration. Only 315 VTE events occurred, so analysis by VTE type was limited. The cohort included only people with HIV in care, so results may not apply to people not in care or not yet diagnosed. Female estimates were less precise because only 19% of participants were female. Never and former cannabis users may have had more baseline VTE risk factors, which could bias the comparison. Follow-up time varied because CNICS is a dynamic cohort.
Declared interests
The supplied text states that the authors report no real or perceived vested interests related to this article.
The easy way to misread this
Do not read this as proof that cannabis has no effect on clot risk for everyone with HIV. The study found no significant association with incident venous thromboembolism, but it did not measure cannabis dose, route, contaminants, or other cardiovascular outcomes.