Can N-terminal pro-B-type natriuretic peptide concentration on admission predict the functional independence measure at discharge in patients aged 75 years or older with postoperative proximal femur fracture?
Shinya Kato, Akio Kamiya, Yosuke Sugimoto and 2 others
PMID 40171183WHAT IT FOUND
In older proximal femur fracture patients, a blood marker of heart failure severity did not predict total independence at discharge beyond the baseline score.
Higher marker levels were linked to lower motor independence and smaller total and motor gains.
Key findings
01NT-proBNP concentration was not associated with total FIM at discharge, cognitive FIM at discharge, or cognitive FIM effectiveness.
02Admission NT-proBNP concentration was associated with lower motor FIM score at discharge.
03Admission NT-proBNP concentration was associated with lower total FIM effectiveness and lower motor FIM effectiveness.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTs
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What it does not show
It was a single-center retrospective study, so the findings may not apply to other hospitals or patients. Only 35 patients were included from 98 initially considered, and the planned sample was 39. 47 patients were excluded because HDS-R was 20 or lower, so the results do not apply to patients with suspected dementia. Heart failure severity was assessed only by NT-proBNP concentration, not by echocardiography or other cardiac measures. Comorbidities and complications that can affect daily function were not examined in detail. All patients were 75 years or older, so it does not speak to younger postoperative patients.
Declared interests
This research received no grant from any funding agency in the public, commercial or not-for-profit sectors. The authors declare that there is no conflict of interest.
The easy way to misread this
Do not conclude that NT-proBNP caused poorer recovery or that it should be used to withhold rehabilitation. This was a retrospective association study in 35 patients, and it did not test treatment.