Can genetics guide exercise prescriptions in osteoarthritis?
Osvaldo Espin-Garcia, Madhu Baghel, Navraj Brar, Jackie L Whittaker, Shabana Amanda Ali
PMID 36188938WHAT IT FOUND
Genetics may eventually help tailor exercise for osteoarthritis, but current evidence is too limited to guide clinical practice.
The authors argue for future research linking genetic markers with exercise response, not for immediate implementation.
What this paper is
This is a perspective article discussing the potential role of genetics and epigenetics in guiding exercise prescriptions for osteoarthritis. It reviews existing literature and proposes future research directions but does not report original methods, results, or clinical outcomes. There is no finding here to act on.
What it does not show
The paper is a theoretical perspective and narrative review, not an empirical study with patient data. It relies on the authors' interpretation of existing literature rather than new evidence. No clinical protocols or exercise prescriptions are tested or validated.
Declared interests
Funding was provided by Henry Ford Health. The authors declare no commercial or financial conflicts of interest.
The easy way to misread this
Do not interpret this paper as evidence that genetic testing can currently guide osteoarthritis exercise prescriptions. The authors state that research at the intersection of genetics, exercise, and osteoarthritis is sparse, and this is a proposal for future work, not a validated clinical tool.