Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.
Hsiang-Yuan Lin, Arthur N Westover, Amy S F Lutz, Manish K Jha
PMID 42222935WHAT IT FOUND
A narrative review with no original findings.
It proposes a model and calls for new research in autistic adults.
What this paper is
This is a narrative review that proposes a conceptual model for understanding irritability in autistic adults, critiques current measurement tools, surveys the neurobiological and pharmacological literature, and calls for new adult-focused clinical trials. It reports no original data, no participants, and no study results. There is no finding here to change practice on.
Declared interests
The authors declare no financial or competing interests. Dr. Lin receives an honorarium for serving as Associate Editor for NeuroImage: Clinical. Dr. Jha has received contract research grants from Neurocrine Bioscience, Navitor/Supernus, and Janssen Research & Development; consultant fees from Janssen, Neurocrine, Abbvie, Sanofi, Definium (MindMed), and Boehringer Ingelheim; and honoraria for educational presentations from multiple sources.