Associations between depression, resilience, and fatigue in patients with multivessel coronary disease: A cross-lag study.
Binbin Sun, Jing Han, Beibei Tian and 3 others
PMID 40241872WHAT IT FOUND
In patients with multivessel coronary disease, higher depression scores were followed by higher fatigue scores, while higher resilience scores were followed by lower fatigue scores and a weaker depression-fatigue link.
Key findings
01Earlier depression was significantly associated with later fatigue: depression on day 3 of admission predicted fatigue one month after discharge (β=0.461), and depression one month after discharge predicted fatigue three months after discharge (β=0.957).
02Earlier resilience was significantly associated with lower later fatigue (β=-0.271 and β=-0.176), and resilience one month after discharge moderated the association between depression on day 3 of admission and fatigue three months after discharge (β=-0.760).
03Depression and fatigue scores decreased from admission to three months after discharge, while resilience scores increased; mean depression was 6.85 on a 0-27 scale then 3.66, resilience 22.57 on a 0-40 scale then 27.29, fatigue 70.32 on a 20-100 scale then 47.97.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
All key variables were self-reported questionnaires, so associations may be inflated by response style. The study did not measure or control for sleep quality, social support, or illness severity, which could affect depression, resilience, and fatigue. Follow-up stopped three months after discharge, so it cannot show what happens later. It was done in three hospitals in Tangshan, China, and excluded patients with severe depression, severe arrhythmias, or hearing or communication disabilities, so results may not apply to those groups. Some enrolled patients were excluded or lost contact, so the analysed group may not represent all patients. Cross-lag models show prospective associations, not proven causation.
Declared interests
This study was supported by the Medical Science Research Project of Hebei. The authors declare no competing interests.
The easy way to misread this
Do not conclude that treating depression or building resilience will reduce fatigue in these patients. The study observed associations over time, but it did not test an intervention, and important factors such as sleep, social support, and illness severity were not measured.