Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women.
Seok-Ki Min, Seung-Taek Lim, Chang-Sun Kim
PMID 27821924WHAT IT FOUND
Older women with the ACTN3 RR genotype had higher trunk, pelvis and spine bone density, but strength, walking, balance and endurance did not differ by genotype.
Key findings
01Bone density differed significantly by ACTN3 genotype in the trunk, pelvis and spine.
02Physical fitness measures did not differ significantly among ACTN3 genotypes.
03Bone density was positively correlated with body muscle mass, and grip strength and dumbbell curl performance were correlated with some bone density sites.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
Only 68 women were studied, and the RR genotype group had just 12 women, so the genotype groups were small. The study compared many bone sites and many fitness measures at once, so a significant difference in one area could be chance. It measured associations at one time, so it cannot show that ACTN3 genotype caused the bone density differences. The study measured genetic association and fitness, not the effect of therapy, so it does not show what treatment changes bone density or fitness.
The easy way to misread this
Do not conclude that the RR genotype causes higher bone density. This was an association study, not a treatment test, and physical fitness did not differ by genotype.