Association between health-related quality of life and nonadherence to antihypertensive medication.

The study design is cross-sectional, so it cannot establish cause and effect. For example, it is unclear if depression causes nonadherence or if nonadherence worsens depression. Data relies on self-reported medication adherence, which may be inaccurate due to recall bias or social desirability bias. The analysis excluded patients who took medication partially (e.g., missed doses), focusing only on daily users versus non-users, which may not reflect the full spectrum of adherence issues. The study did not account for comorbidities, which could influence both quality of life and medication adherence.

The study used data from the Korea Disease Control and Prevention Agency. The authors declared no conflicts of interest.

Do not conclude that mobility problems cause women to take their medication more often. The association may reflect other factors, such as increased healthcare contact or caregiver assistance, and the cross-sectional design cannot determine causality.