Among 110 cancer patients before their first chemotherapy, higher comorbidity scores and lower functional status were weakly but significantly associated with early heart muscle impairment. These routine scores may help prioritise who gets a baseline echo.
68 patients (61.8%) already had reduced global longitudinal strain before receiving any chemotherapy, meaning subclinical systolic impairment was common even in treatment-naive patients.
Higher comorbidity burden was modestly associated with worse global longitudinal strain and higher E/e' ratio, while better functional status correlated with more preserved strain; age was also linked to higher filling pressures.
In the multivariable model, age remained an independent predictor of E/e' ratio, while the comorbidity index showed only borderline significance, and cancer type and sex were not associated with any cardiac parameter.
Single-blind randomized controlled trial. Sixty-four participants were randomized across two intervention arms and assessed at twelve weeks for the primary outcome…
Create a free account to read the methodology, results and clinical relevance — three full summaries a month, no card.
Summarised by AI from the abstract, not the full paper. Check it against the source before it changes what you do. Read it on PubMed →