PTSystematic ReviewProsthetics and orthotics international2025

Analyzing research trends and developments in osseointegration in patients with extremity amputations: Systematic bibliometric analysis and research recommendations.

Raphael-Kyrillos M Saleib, Begüm Pekbay, Michiel H J Verhofstad and 3 others

PMID 39514709

WHAT IT FOUND

Research on bone-anchored prostheses for limb amputations has grown, with most work on lower-extremity osseointegration, rehabilitation, quality of life, complications, and implant treatment.

It maps topics and gaps, not patient outcomes.

Key findings

01The included articles span 1993 to 2023, with an annual growth rate of 10.3%, and 112 articles were included for analysis.

02Author keywords were most frequent for osseointegration (58), amputation (32), and transfemoral amputation (25), while KeyWords Plus most frequent were rehabilitation (40), quality of life (37), and transfemoral amputation (37).

03Research collaborations were mainly among high-income countries, and direct comparative studies on one-stage versus two-stage osseointegration surgery are lacking.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

This is a bibliometric review, so it counts publications and citations, not patient outcomes. The search used database metadata, so it may have missed paper quality, overlapping patient populations, or studies not indexed. It focused on clinical articles and excluded animal or fundamental studies, so laboratory work may be underrepresented. Citation counts and metadata can change after publication. Terminology and naming differences may bias keyword and author rankings. No authors or subject experts were contacted, and unindexed journals were not browsed.

Declared interests

No financial support was received, and the authors disclosed no potential conflicts of interest.

The easy way to misread this

Do not read this as evidence that bone-anchored prostheses improve walking, quality of life, or complications. It maps publication trends, citation counts, and research gaps, not patient outcomes.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →