Analysis of the vaccination situation against Mpox in people living with HIV/AIDS: an ecological study.
Núbia Vanessa da Silva Tavares, Amuzza Aylla Pereira Dos Santos, Mariana Maria Pereira Cintra Farias Carvalho and 5 others
PMID 39476043WHAT IT FOUND
Mpox vaccination coverage among eligible people living with HIV/AIDS in Brazil was 18.3%, with large regional gaps and many people not completing the second dose.
Nurses can check status and reinforce the two-dose schedule.
Key findings
01A total of 2,978 Mpox vaccine doses had been administered to PLWHA in Brazil, corresponding to 18.3% vaccination coverage.
02Regional coverage varied widely, from 3.5% in the South to 32.8% in the Southeast.
03First-dose and second-dose proportions differed noticeably across all regions, with the North lowest for both.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
This is an ecological study of aggregated public data, so it cannot show individual outcomes, vaccine effectiveness, or why people did not complete vaccination. The data were collected in April 2023 during an ongoing outbreak, so coverage may have changed after the study. The authors could not tell whether the gap between first and second doses reflected people abandoning the schedule or the 30-day interval, because the data did not show when vaccination schedules started. The eligible population denominator came from PLWHA with at least one CD4 test in the public system in late 2022, so people not tested or outside the public system may not be counted. The paper reports no clinical outcomes such as Mpox infection, severity, or mortality.
The easy way to misread this
Do not read the low coverage or the first-to-second dose gap as proof that the Mpox vaccine is ineffective or that PLWHA refused it. This ecological study reports only doses and coverage from public data, not individual outcomes, and the authors say they could not tell whether incomplete schedules reflect abandonment or the 30-day interval because start dates were unavailable.