SLPCohortCoDAS2026

Analysis of neural coding of speech in monaural and binaural conditions in children with speech sound disorder.

Marciana da Costa Carlos, Thaís Nobre Uchôa Souza, Ranilde Cristiane Cavalcante Costa and 1 others

PMID 42585410

WHAT IT FOUND

Children with phonological disorder showed longer brainstem responses to a speech sound than typically developing children, in every listening condition tested.

This objective measure could complement clinical assessment, but the study does not show it tracks therapy progress.

Key findings

01Wave V latency of the Frequency Following Response was longer in children with phonological disorder than in typically developing children across all three stimulation conditions (right monaural, left monaural, binaural), with a significant group effect (p = 0.006).

02FFR amplitude did not differ significantly between the two groups (p = 0.055), meaning amplitude was not sensitive enough to distinguish children with phonological disorder from typically developing children in any condition.

03Binaural stimulation produced significantly larger amplitudes than either monaural condition (p < 0.001), a binaural summation effect that was consistent across both groups, while no significant difference was found between the right and left monaural conditions (p > 0.05).

STILL TO COME

How it was doneWhat they foundWhat it means for SLPs

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What it does not show

Cross-sectional design: a single time-point comparison cannot show that the latency difference is caused by the phonological disorder, that it changes with therapy, or that it predicts outcomes. It shows an association, not a trajectory. Small sample: 21 children per group at a single site. The amplitude result (p = 0.055) sits just above the conventional threshold, and with a larger sample the picture could shift. Control group was selected by convenience sampling rather than drawn from the same clinical population, which may introduce subtle differences in background, language exposure, or socioeconomic factors. Socioeconomic and environmental variables (maternal education, family income, school type) were not controlled or matched between groups, and the authors acknowledge this as a limitation that could confound the results. No correlational analysis was performed between the severity of the phonological disorder (PCC-R scores) and the FFR parameters; the authors state this is the subject of a separate study. The FFR stimulus was a single syllable (/da/), so the findings speak to encoding of one specific speech sound and may not generalise to all phonemes or to connected speech. Children were awake and watching a silent film during recording; the effect of this on FFR quality compared to sleep recordings is not discussed.

Declared interests

Funded by FAPEAL, a state research foundation in Alagoas, Brazil (grant E:60030.0000001502/2023). No industry funding, no conflicts of interest declared, and no commercial entity was involved in study design, data collection, or manuscript preparation.

The easy way to misread this

Do not read this as evidence that FFR is now a validated diagnostic test for speech sound disorder or a tool for monitoring therapy progress. The study is a single cross-sectional comparison of 42 children at one site; it shows that wave V latency is longer in children who already have a clinical diagnosis of phonological disorder, but it does not show that FFR can make that diagnosis, that it changes with treatment, or that it predicts which children will respond to intervention. The authors themselves state that FFR should be understood as a complementary examination and that longitudinal studies are needed to evaluate whether FFR tracks therapeutic progress.

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The study

Participants
42 children (21 with phonological disorder, 21 typically developing), ages 4 to 7 years 11 months, matched for sex and age
Certainty of evidence
Low

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Cite

Marciana da Costa Carlos, Thaís Nobre Uchôa Souza, Ranilde Cristiane Cavalcante Costa, et al. Analysis of neural coding of speech in monaural and binaural conditions in children with speech sound disorder. CoDAS. 2026.

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