An Evaluation of the Multifactorial Model of Cancer-Related Cognitive Impairment.
Kate R Oppegaard, Samantha J Mayo, Terri S Armstrong and 8 others
PMID 37104681WHAT IT FOUND
A model putting all four risk groups together did not show a clear combined effect, but fatigue, anxiety, sleep, depression and pain had the strongest link to self-reported cognitive impairment among chemotherapy patients.
Key findings
01The simultaneous model estimating the joint effect of all four latent variables was not significant.
02Co-occurring symptoms explained the largest amount of variance in cancer-related cognitive impairment, even after controlling for social determinants, patient-specific factors, and treatment factors.
03Treatment factors had the smallest standardized effect on the cognitive impairment latent variable among the four concepts evaluated.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The analysis used one time point before the second or third chemotherapy cycle, so it cannot show how cognitive problems change during treatment or which factors cause them. Cognitive impairment was measured only by self-report on the Attentional Function Index, not by objective cognitive testing. The simultaneous model with all four latent variables was not significant, so the joint effect of the four concepts was not demonstrated. Gender and type of cancer were nominal variables and could not be evaluated as part of the latent variables. The models were built from available data, so other indicator variables might produce different findings. The sample was mostly female, White, receiving only chemotherapy, and receiving chemotherapy on a 21-day cycle, so results may not apply to other groups.
The easy way to misread this
Do not conclude that treating fatigue, anxiety, sleep, depression, or pain will improve chemotherapy-related cognitive problems. The study measured associations at one time point and did not test any treatment.