Adverse Outcomes and Associated Factors Among Children and Youths With Diabetes Mellitus in East Africa: A Systematic Review and Meta-Analysis.
Chalie Marew Tiruneh, Marilyn Cruickshank, Muhammad Chutiyami and 1 others
PMID 40755180WHAT IT FOUND
Children and youths with type 1 diabetes in East Africa often had poor glucose control, ketoacidosis at diagnosis, complications, and deaths.
No type 2 diabetes studies were found.
Key findings
01Poor glucose control and ketoacidosis were common among children and youths with diabetes in East Africa.
02Pooled mortality among children and youths with diabetic ketoacidosis was 6.47%.
03No studies addressing T2DM in this age group were found.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Only six East African countries were represented, so the findings may not reflect the whole region. Most included studies were cross-sectional, so they show association at one point rather than cause. Studies used different HbA1c targets and DKA criteria, making direct comparison difficult. The review found no studies of type 2 diabetes in children and youths in East Africa. High heterogeneity was present in pooled estimates for mortality and quality of life. Included studies had limitations in identifying and managing confounding factors.
Declared interests
The authors declared no conflicts of interest. Funding is listed as the Australian Government Department of Education.
The easy way to misread this
Do not read these proportions as evidence that any diabetes education or insulin strategy works. The review describes outcomes and associated factors in observational studies, and it found no type 2 diabetes studies in this age group.