Advancing evidence-based practice through the Knowledge Translation Challenge: Nurses' important roles in research, implementation science and practice change.

This is a program description and a single case study, not a controlled trial, so it cannot show that the toolkit alone caused the changes. The clozapine toolkit was delivered with several components at once, including guideline, preprinted orders, monitoring flowsheet, online course, medication discharge summary and patient handout, plus staff education, in-person support, chart audits and pharmacy workflow changes; the contribution of any single component cannot be separated. The chart review analysed 298 admissions at one acute mental health unit, so it may not apply to other settings or patient groups. The paper reports documentation and monitoring adherence, not patient clinical outcomes such as relapse, side effects or mortality. Across the wider program, 15 of 30 teams demonstrated uptake, five more had anecdotal uptake, seven were still active, three withdrew and some teams were still within term, so the program result is incomplete.

The program was supported by Providence Health Care Professional Practice Office, St Paul's Foundation, Vancouver Coastal Health Research Institute, the Robert H. N. Ho Enhancing Patient Care Fund supported by the VGH & UBC Hospital Foundation, and BC Cancer. The authors declared no conflicts of interest.

Do not read the 96% preprinted order use or 66% success rate as proof that the toolkit improves patient health outcomes. The paper reports implementation and documentation measures from a single before-after project and program reports, with no control group and no patient clinical outcomes.