RNRCTNursing in critical care2026

Acceptability and Fidelity of a Cognitive Rehabilitation Intervention During and After Intensive Care: A Feasibility Evaluation.

Katrine Astrup, Anna Holm, Helene Korvenius Nedergaard and 2 others

PMID 42304649

WHAT IT FOUND

ICU patients and nurses rated mindfulness and brain training as relevant, but use was uneven and depended on energy, timing and support.

This shows feasibility, not that the intervention improved cognition.

Key findings

01Patients and nurses generally rated Mindfulness and Brain Training as relevant and appropriate to patient energy level.

02Fidelity varied across settings: Mindfulness was often nurse-supported during ICU admission, while after discharge most Mindfulness responses were completed independently.

03The study measured acceptability and fidelity, not clinical effectiveness, and small samples made findings exploratory.

STILL TO COME

How it was doneWhat they foundWhat it means for RNs

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What it does not show

This was a feasibility evaluation of acceptability and fidelity, not a test of whether ICU CogHab improves cognition or recovery. Only 31 patients completed at least one follow-up survey, although 83 patients were enrolled in the parent trial, and only 9 patients and 7 nurses were interviewed. Data came mainly from patients who engaged with the intervention, so patients who refused, did not use it or did not complete follow-up were not represented. The study was not designed for formal comparison between intervention groups or sites, and small numbers made findings exploratory. Nurse delivery depended on workload, shift patterns, competing tasks and local ICU conditions, so consistency varied. Survey items were brief and had missing responses, limiting the precision of quantitative fidelity estimates.

Declared interests

Novo Nordisk Foundation and Aarhus University supported the study. The authors declared no conflicts of interest. ChatGPT was used for editorial language refinement only, and the authors reviewed and edited the content.

The easy way to misread this

Do not conclude that ICU CogHab improves cognition or post-ICU recovery. This feasibility evaluation measured acceptability and fidelity, and the small sample did not test clinical effectiveness.

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The study

Participants
83 patients were enrolled in the parent feasibility trial; 31 patients completed at least one follow-up survey and 9 patients were interviewed; 53 nurses completed 194 ICU registrations and 7 nurses were interviewed.
Certainty of evidence
Moderate

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Katrine Astrup, Anna Holm, Helene Korvenius Nedergaard, et al. Acceptability and Fidelity of a Cognitive Rehabilitation Intervention During and After Intensive Care: A Feasibility Evaluation. Nursing in critical care. 2026.

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