A single-arm feasibility study protocol for a multiphasic multimodal exercise prehabilitation intervention in individuals receiving allogeneic stem cell transplant.
Chad W Wagoner, Julia T Daun, Jocelyn Cannon and 5 others
PMID 40130731WHAT IT FOUND
This paper describes a planned 30-week exercise program for stem cell transplant patients, delivered by clinical exercise physiologists across three phases.
It is a protocol only, so no results, feasibility data, or clinical outcomes are reported yet.
Key findings
01The study is a protocol for a single-arm feasibility trial of a multiphasic multimodal exercise intervention.
02The intervention spans up to 30 weeks, covering pre-transplant consolidation, inpatient transplant, and post-transplant outpatient recovery.
03The primary outcome is feasibility, assessed through adherence and fidelity, with physical function and patient-reported outcomes as secondary measures.
STILL TO COME
How it was doneWhat they found
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What it does not show
This is a protocol paper, meaning it describes a plan for future research and contains no actual data or findings. The study design is single-arm, so it will not be able to determine if the exercise intervention caused any changes in outcomes compared to standard care. The sample size calculation (n=52) is based on detecting a change in physical activity, not clinical function, which may limit the generalizability of future findings to broader rehabilitation goals.
Declared interests
The study is supported by an Investigator Initiated Trial grant through the Tom Baker Cancer Centre and Alberta Cancer Foundation. The authors declare no conflicts of interest.
The easy way to misread this
Do not interpret this paper as evidence that this exercise program works or is feasible for stem cell transplant patients. It is a protocol describing what the researchers plan to do and measure in the future, not a report of what happened to actual patients.