A multifaceted approach for analyzing complex phenotypic data in rodent models of autism.
Ishita Das, Marcel A Estevez, Anjali A Sarkar and 1 others
PMID 30911366WHAT IT FOUND
No clinical action is available.
The paper reports a database of rodent autism models and drug rescue records, not human patients, therapy outcomes, or treatments tested in people.
Key findings
01The rodent dataset represents phenotypes from 345 ASD factors taken from 787 references.
02The most frequently annotated phenotypes were general locomotor activity, anxiety, and social interaction.
03In Shank3 mouse models, anxiety and self-grooming were increased in all tested homozygous knockout mouse models.
STILL TO COME
How it was doneWhat they found
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What it does not show
The study reports rodent models, not human patients. It cannot show what a therapist should do with a person. The annotation records only differences from controls reported as statistically significant. Null findings may be underrepresented. Drug rescue records are animal experiments. They do not establish efficacy or safety in people. The data freeze date is stated in the methods. Newer evidence is not included. The paper is a database resource and case study, not a trial or therapy outcome study.
Declared interests
The supplied metadata lists non-U.S. government research support. The text does not provide an author conflict-of-interest statement.
The easy way to misread this
Do not read the rodent rescue drug records as evidence that any drug works in people with autism. The paper describes animal models and curated literature, not human trials or therapy outcomes.